Human Sera
Cayman Chemical TMPyP4tosylate 100mg
A cationic porphyrin that intercalates into and stabilizes G-quadruplexes; inhibits telomerase activity (IC50 ≤ 50 µM), blocking the clonogenic growth and migration of cancer cells in culture and in vivo
Cayman Chemical N6Methyl2deoxyadenosIn 100mg
A nucleoside and inducer of EPC proliferation; stimulates the proliferation of EPCs isolated from mouse fetal livers and colony formation of isolated mouse bone marrow cell-derived progenitor cells at 10 and 100 µM; accumulates along promoters and gene coding sequences in activated mouse prefrontal cortical neurons; is associated with activation at the Bdnf promoter
Cayman Chemical NaloxonhydrochlorIde 100mg
An analytical reference standard categorized as an opioid antagonist; formulations containing it have been used as antidotes for opioid overdose and the prevention of overdose; formulations containing it have also been used in the treatment of opiate addiction and in pain management; intended for research and forensic applications
Cayman Chemical GalntamInhydrobromIde 50mg
An alkaloid with AChE inhibitory and nAChR potentiating activities; selectively inhibits AChE over BChE (IC50s = 636 and 8,404 nM, respectively); potentiates ACh-induced currents in HEK293 cells expressing human α4β2 subunit-containing nAChRs at 0.5 µM; decreases escape latency and path length in the Morris water maze in the APP23 transgenic mouse model of Alzheimer's disease at 1.3 mg/kg per day
Cayman Chemical SBE 13hydrochlorIde 50mg
A potent inhibitor of Plk1(IC50 = 0.2 nM) that targets the inactive conformation of the enzyme; exhibits no activity against aurora A kinase and less effectively inhibites Plk2 (IC50 > 66 µM) and Plk3 (IC50 = 875 nM); induces cell cycle arrest, reduces cell proliferation, and induces apoptosis
Cayman Chemical AlarelInacetate 100mg
A peptide agonist of GnRH; binds to GnRHR (Kd = 0.2 nM); decreases GnRH and GnRHR expression in the preoptic area and pMBH, respectively, of ovariectomized estradiol-treated rats at 6 ng, i.c.v., indicating an ultrashort negative feedback loop; induces desensitization in the pituitary and decreases serum estradiol levels and ovarian and uterine weight in neonatal and adult female rats; reduces tumor growth in an HEC-1-B mouse xenograft model at 20, 40, and 80 UG/mg
Cayman Chemical ToltrazurIl sulfon 50mg
An active metabolite of toltrazuril; formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by CYP enzymes, including CYP3A; inhibits T. gondii tachyzoite production in African green monkey kidney cells at 0.1, 1, and 5 UG/ml; completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis at 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection; reduces the number of infected mice in the same model at 10 mg/kg for 11 days starting six days following infection
Cayman Chemical SuberylglycIn 50mg
A glycine-conjugated form of suberic acid; urinary levels are increased in patients with MCAD deficiency
Cayman Chemical IsoImperatrIn 50mg
A natural furanocoumarin that inhibits CYP1A activity, in particular blocking hepatic EROD activity; also induces the expression of GSTα by activating Nrf2
Cayman Chemical 9-Phenthrol 100mg
A TRPM4 inhibitor (IC50s = 19.1, 17.1, and 22.8 µM at +40, -40, and -80 mV, respectively, in HEK293 cells expressing the human receptor); selective for TRPM4 over TRPM5 at 100 µM; reduces heart rate in spontaneously beating isolated mouse right atria at 100 µM; reduces infarct size and apoptosis in isolated rat hearts in an ex vivo model of ischemia-reperfusion injury; reduces myogenic tone in rat cerebral arteries in vivo
Cayman Chemical PropargylcholInbromIde 100mg
An alkynyl derivative of choline that has a propargyl group in place of one methyl group; can be used to assay phospholipid synthesis and localization in cells and tissues using Raman scattering microscopy or click chemistry labeling with fluorescent or affinity-tagged azides; inhibits growth of P. aeruginosa on dimethylglycine (IC50 = 5.16 μM), choline, and glycine betaine
Cayman Chemical Lonurus artmsa Lonurn 50mg
An alkaloid that has diverse biological activities; reduces infarct size and collagen deposition and inhibits apoptosis of cardiomyocytes in a coronary artery ligation-induced rat model of myocardial infarction at 15 mg/kg per day; increases hepatic levels of SOD and GSH, reduces serum ALT and AST levels, and inhibits hepatic fibrosis in a diet-induced mouse model of NASH at 200 mg/kg per day; inhibits LPS-induced increases in TNF-α, IL-1β, and IL-6 levels in the serum of broiler chicks at 120 mg/kg
Cayman Chemical DIflucortolon 21valerAT 100mg
A glucocorticoid; has anti-inflammatory effects in a rat model of croton oil-induced EAr edema when applied topically (ED50 = 9.7 UG/ml); induces skin inflammation and thins the epidermis in hairless dogs following chronic topical administration at 0.1%; increases allergic- and non-allergic-mediated skin inflammation in mouse models of atopic dermatitis when applied topically prior to and following sensitization
Cayman Chemical TIrapazamIn 50mg
A hypoxia-activated anticancer agent; is converted to an oxidizing radical under hypoxic conditions; can induce single- and double-strand breaks in DNA, formation of trapped topoisomerase I- and II-DNA complexes, and other chromosomal aberrations, leading to cytotoxicity; induces hypoxia-enhanced cytotoxicity in DT40 cells (IC50s = 1.02 and 4.34 μM in hypoxic and normoxic conditions, respectively); induces cytotoxicity in HT-1080 and A549 cells in a concentration-dependent manner under hypoxic conditions; sensitizes tumors to cisplatin in a mouse RIF-1 fibrosarcoma tumor model; sensitizes tumors to fractionated irradiation in a FaDu hypopharyngeal squamous cell carcinoma mouse xenograft model at (0.08 mmol/kg)